Non-Linear Mixed Effects Modeling using Pumas

16 Apr 2020 |

Registration for the workshop is available as part of your registration for the Annual Conference on Pharmacometics

Course Description

In this two-day workshop, participants will be introduced to the newly released Pumas software for modeling and simulation. Participants will be provided an introduction to the Julia Language and via hands-on exercises learn how to use the software. This workshop is designed for beginners and relatively experienced individuals dealing with clinical pharmacology related data analytics in their day to day work. Individuals interested in performing Non-compartmental analysis on their clinical data or use basic or advanced non-linear mixed-effects models to capture the variability in drug pharmacokinetics or response and the contribution of covariate effects and/or simulate new dosing scenarios or clinical trials will find this workshop interesting. Participants with experience in NLME workflows would see the benefit of Pumas workflows over current tools.


The software and all material will be made available to the participants a few weeks before the workshop. The software is free to use for academic and non-commercial purposes and a license is required for commercial use. All materials will be hosted on github.


Vijay Ivaturi, Christopher Rackauckas, Vaibhav Dixit, Patrick Mogensen, Andreas Noack

Workshop Outline (Tentative)

October 3, 2020  
Time Activity
7:30 - 8:30 Registration and Breakfast
8:30 - 9:00 Demo on Julia and JuliaPro
9:00 - 10:00 Data Munging and Plotting in Julia
10:0 - 10:30 Handson - I
10:30 - 12:00 Pumas Model Interface
13:00 - 14:00 Designing Dosage Regimens
14:00 - 15:00 Handson - II - Simulating Dosing Regimens
15:15 - 16:30 Simulating discrete data models
October 4, 2020  
7:30 - 8:30 Breakfast
8:30 - 9:30 NLME Estimation - Maximum Likelihood
9:30 - 10:00 Handson - I
10:15 - 11:00 NLME Estimation - Bayesian
11:00 - 12:00 Handson -II
13:00 - 14:00 Model Diagnostics
14:00 - 15:00 Handson - III - Model diagnostics and evaluation
15:15 - 16:30 Advanced tips and tricks


Industry: $800
Academia/Government: $500
Students/Post-docs: $200


Main registration site for ACoP11