Hear how an industry team used Pumas® to achieve more than 25x faster NLME model runtimes during a complex exposure-response analysis.

In this client-led webinar, scientists from Indivior share their experience using Pumas to accelerate a large-scale exposure-response (E-R) modeling program evaluating extended-release buprenorphine (BUP-XR) in patients with opioid use disorder.

The challenge: Faced with a complex integrated analysis spanning two clinical studies (N=989), increasing prevalence of fentanyl and polysubstance use, and demanding timelines, the team needed a faster way to develop, evaluate, and report NLME models across multiple efficacy endpoints.

Find answers to questions like:

• Why the team chose Pumas for a complex population PK and E-R modeling workflow
• How they analyzed opioid use, opioid craving, and treatment retention using NLME and time-to-event methods
• How model runtimes were reduced from days to hours, enabling a more efficient workflow and faster decision-making
• How rapid generation of diagnostics, goodness-of-fit plots, and visual predictive checks streamlined reporting
• Key scientific findings on buprenorphine exposure in patients with fentanyl and polysubstance use

Highlights

• Hear directly from an industry customer, not PumasAI
• Learn how tight modeling timelines were successfully managed
• See a real-world case study of accelerated NLME model development
• Discover how Pumas supported the execution of more than 700 model runs and enabled on-time delivery of results

Duration: 1 hour

Speakers: Lauren Lohmer, PhD (Indivior); Celine Laffont, PhD (Indivior); Andreas Noack, PhD (PumasAI)

Watch now!