In this session, we run an NCA (parameter estimation, λz selection, partial AUCs), then move into bioequivalence (log-transformed ANOVA, 90% CI against 80–125%, and HVD considerations), dose proportionality, and superposition for accumulation prediction — and show how to templatize each workflow for reuse across studies.

After watching this you will be able to:

• Run an NCA, including λz/terminal-phase selection and partial AUCs
• Set up an average BE assessment and read the result against acceptance limits
• Assess dose proportionality
• Apply superposition to anticipate steady-state behavior
• Build reusable analysis templates to standardize and rerun work across studies

Topics/sub-topics

• NCA: parameters, λz selection, partial AUCs, exclusion/flagging semantics
• BE: ANOVA on log-transformed data, within-subject CV, T/R GMR, 90% CI; ABE vs RSABE for HVDs and replicate designs
• Dose proportionality (power-model approach)
• Superposition and accumulation prediction
• Templatizing tasks for reuse and consistency
• Agent Spotlight: agent-driven analysis setup

Duration: 1 hour

Speaker: Dr. H J Sharath Kumar, Product Specialist (PumasCP)

Watch now!

Related webinars:

Getting Started with PumasCP: Platform Tour & Building Analysis-Ready Datasets
Publication-Quality PK Graphics: Plotting from scratch or using Templates
Drafting the PK CSR in PumasCP