Date: May 27, 2026, 11am ET

Duration: 1 hour

Instructor: Dr. David Müller-Widmann

Cortés-Ríos et al. (CPT:PSP, 2025) recently proposed a step-by-step workflow for performing in-silico clinical trials with nonlinear mixed-effects (NLME) models. In this webinar, we demonstrate that workflow in Pumas on an 11-ODE QSP model of chronic hepatitis B (Cortés-Ríos et al., Clin Pharmacol Ther 2025).

The session covers:

• Defining the published NLME model in Pumas
• Global sensitivity analysis (Sobol, eFAST) to rank parameter influence
• Structural identifiability assessment under different measurement scenarios
• Virtual population generation via Gaussian copulas
• Calibration of the virtual population to clinical distributions using  mixed-integer linear programming (MILP)
• Multi-arm virtual trial simulation and visualization of outcome distributions

Whether you are working in pharmacometrics, systems pharmacology, or model-informed drug development, this webinar offers a practical look at how ISCT workflows can be implemented in a modern computational framework.

Register here!