Cortés-Ríos et al. (CPT:PSP, 2025) proposed a step-by-step workflow for performing in-silico clinical trials with nonlinear mixed-effects (NLME) models. In this webinar, we demonstrate that workflow in Pumas on an 11-ODE QSP model of chronic hepatitis B (Cortés-Ríos et al., Clin Pharmacol Ther 2025).

The session covers:

• Defining the published NLME model in Pumas
• Global sensitivity analysis (Sobol, eFAST) to rank parameter influence
• Structural identifiability assessment under different measurement scenarios
• Virtual population generation via Gaussian copulas
• Calibration of the virtual population to clinical distributions using mixed-integer linear programming (MILP)
• Multi-arm virtual trial simulation and visualization of outcome distributions

Whether you are working in pharmacometrics, systems pharmacology, or model-informed drug development, this webinar offers a practical look at how ISCT workflows can be implemented in a modern computational framework.

Instructor: David Müller-Widmann, PhD

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