Publications

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Poster

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Vaccine Development

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NLME

Evaluating the impact of codon usage, GC Content, and secondary structure on in vitro mRNA protein expression using non-linear mixed effect modeling

Sharath Kumar, Saugandhika Minnikanti, Niklas Korsbo, Ajay Singh, Rohan Gurjar, Tejas Borwankar, Swarnendu Kaviraj, Vijay Ivaturi

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Podium

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Model-informed Vaccine Development

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Evaluating the impact of codon usage, GC Content, and secondary structure on in vitro mRNA protein expression using non-linear mixed effect modeling

Sharath Kumar, Saugandhika Minnikanti, Niklas Korsbo, Ajay Singh, Rohan Gurjar, Tejas Borwankar, Swarnendu Kaviraj, Vijay Ivaturi

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Poster

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MIDD

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PopPK Modeling & Simulations

Model Informed Dose Optimization Of Balstilimab To Support Fixed Dosing Alone And In Combination With Botensilimab In Patients With Solid Tumors

Mélanie Wilbaux, Zhengqi Tan, Amit Roy, Joseph Grossman, Dhan Chan, Gerald Fetterly

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Poster

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MIDD

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PopPK Modeling & Simulations

Model Informed Dose Optimization Of Botensilimab Alone And In Combination With Balstilimab In Patients With Solid Tumors

Zhengqi Tan, Mélanie Wilbaux, Amit Roy, Joseph Grossman, Dhan Chan, Gerald Fetterly

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Poster

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Multiple Ascending Dose Study NCA

Sharath Kumar

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Poster

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Antibiotic therapy in battlefield scenario

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Exposure Efficacy

Probability of Target Attainment Analysis for Antibiotic Therapy in a Virtual Population of Soldiers with Battlefield Injuries

Architha Aithal, Mike Tagen, Jesse Deluca, Vijay Ivaturi

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Abstract

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Oncology

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DeepNLME

A DeepNLME-based Tumor Growth Dynamics and Overall Survival Model for Non Small Cell Lung Cancer

Mohamed Tarek, Lorenzo Contento, Amit Roy, Kiran Gauthier, Anna Kondic, Jun Shen

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Poster

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Oncology

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DeepNLME

A DeepNLME-based Tumor Growth Dynamics and Overall Survival Model for Non Small Cell Lung Cancer

Mohamed Tarek, Lorenzo Contento, Amit Roy, Kiran Gauthier, Anna Kondic, Jun Shen

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Poster

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Neurology, Pain

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A First in Human Study Evaluating the Safety, Tolerability, and Pharmacokinetics of BHV-2100, a TRPM3 Antagonist in Development for Migraine and Pain

Volkan Granit, Richard Bertz, Andrew Lucas, Eric Ashbrenner, Mary Donohue, Patricia Mydlow, Christopher Jensen, Joris Vriens, Thomas Voets, Beth Emerson, Irfan Qureshi, Vladimir Coric.

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Publication

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Complex Covariates

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DeepLearning

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Poster

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DeepNLME, Images

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Abstract

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DeepNLME, Images

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Publication

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Oncology

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A Model-Informed Drug Development Approach to Design a Phase 3 Trial of Teverelix Drug Product in Advanced Prostate Cancer Patients with Increased Cardiovascular Risk

Chenna Keshava Reddy Sannala, Carol MacLean, Finn Larsen, Steve van Os, Pravin Jadhav, Neal Shore, Alicia K. Morgans, Tochukwu Okwuosa, Joga Gobburu

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Podium

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Bayesian NLME

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Bayesian inference of pharmaceutical models with Pumas - A showcase of Julia for high performance interactive computing

David Widmann

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Poster

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Neurology, Pain

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BHV-2100, a First-in-Class TRPM3 Antagonist in Development for the Treatment of Migraine

Beth Emerson, Anne Pieters, Beth Morris, Andrew Lucas, Volkan Granit, Christopher Jensen, Joris Vriens, Thomas Voets, Irfan Qureshi, Vladimir Coric, Richard Lipton

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Publication

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MIEE

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Bioequivalence study followed by model-informed dose optimization of a powder for oral suspension of 6-mercaptopurine

Bhavatharini Arun, Mahendra Joshi, Archana Khosa Kakkar, Shivkumar Madki, Vijay Ivaturi, Girish Chinnaswamy, Shripad Banavali, Vikram Gota

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Podium

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Ophthalmology, Longitudinal biomarkers

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DeepNLME

Charting New Paths In Ophthalmology With DeepNLME-Powered Predictive Modeling​

Niklas Korsbo

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Abstract

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Oncology

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DeepNLME

Data-Driven Discovery of Feedback Mechanisms in Acute Myeloid Leukaemia

Carl Julius Martensen, Niklas Korsbo, Sebastian Sager, Vijay Ivaturi

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Poster

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Oncology

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DeepNLME

Data-Driven Discovery of Feedback Mechanisms in Acute Myeloid Leukaemia

Carl Julius Martensen, Niklas Korsbo, Vijay Ivaturi, Sebastian Sager

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Poster

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Myelofibrosis Anemia

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PKPD modeling

Development of a pharmacokinetic-pharmacodynamic model to describe blood hepcidin levels in patients with myelofibrosis and assess target engagement of zilurgisertib, an ALK2 inhibitor

Ikhlas Guermi, Beatriz Guglieri-Lopez, Phil Wang, Betty Lamothe, Amanda McBride, Jennifer Sheng, Xuejun Chen, Yan-ou Yang

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Abstract

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Myelofibrosis Anemia

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PKPD modeling

Development of a pharmacokinetic-pharmacodynamic model to describe blood hepcidin levels in patients with myelofibrosis and assess target engagement of zilurgisertib, an ALK2 inhibitor

Ikhlas Guermi, Beatriz Guglieri-Lopez, Phil Wang, Betty Lamothe, Amanda McBride, Jennifer Sheng, Xuejun Chen, Yan-ou Yang

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Publication

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Infectious Diseases

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PBPK

Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures

Sanjay Jain, Xueyi Chen, Bhavatharini Arun, Oscar Nino Meza, Mona Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth Tucker, Laurence Carroll, Joel Freundlich, Charles Peloquin, Vijay Ivaturi

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Poster

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Evaluation of Large Language Models for an AI Chat Assistant Focused on Pumas and Pharmacometrics

Agastya Deepak Vinchhi, Juan José González Oneto, Vijay Ivaturi

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Publication

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Generic Drug Development

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Exploration of the potential impact of batch-to-batch variability on the establishment of pharmacokinetic bioequivalence for inhalation powder drug products

Shuhui Li, Kairui Feng, Jieon Lee, Yuqing Gong, Fang Wu2, Bryan Newman, Miyoung Yoon, Lanyan Fang, Liang Zhao, Jogarao V. S. Gobburu

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Poster

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Attention deficit hyperactivity disorder ( ADHD) in adults

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Exposure-Efficacy and Exposure-Safety analyses

Exposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder

Yanlin Wang, Asma Baliouze, Mélanie Wilbaux, Viki Cotero-Lefevre, Susan Shoaf, Osman Turkoglu, Joga Gobburu, Xiaofeng Wang

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Abstract

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Exposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder

Yanlin Wang, Asma Baliouze, Mélanie Wilbaux, Viki Cotero-Lefevre, Susan Shoaf, Osman Turkoglu, Joga Gobburu, Xiaofeng Wang

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Poster

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PopPK modeling in new settings (e.g. indication, population)

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PopPK Regulatory submission

How to handle population pharmacokinetics modeling in the context of a regulatory submission for a compound already well-characterized in other settings? A case-study with nivolumab in urothelial cancer

Mélanie Wilbaux, Yue Zhao, Anna Kondic, Lora Hamuro, Amit Roy

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Abstract

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PopPK modeling in new settings (e.g. indication, population)

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PopPK Regulatory submission

How to handle population pharmacokinetics modeling in the context of a regulatory submission for a compound already well-characterized in other settings? A case-study with nivolumab in urothelial cancer.

Mélanie Wilbaux, Yue Zhao, Anna Kondic, Lora Hamuro, Amit Roy

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Publication

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Vaccines

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Immunostimulatory/Immunodynamic model of mRNA-1273 to guide pediatric vaccine dose selection

Vijay Ivaturi, Husain Attarwala, Weiping Deng, Baoyu Ding, Sabine Schnyder Ghamloush, Bethany Girard, Javid Iqbal, Saugandhika Minnikanti, Honghong Zhou, Jacqueline Miller, Rituparna Das

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Podium

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Improvement of simulation performance and VPCs in a model for a drug with a complex absorption profile

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Non-parametric fitting of the distribution of the random effects using a normalizing flow

Improving simulations by learning the true random effects distribution from a population using generative machine learning

Lorenzo Contento

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Abstract

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DeepNLME

Improving simulations by learning the true random effects distribution from a population using generative machine learning

Lorenzo Contento, Mohamed Tarek

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Podium

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Identifiability

Make models great again by optimally restricting parameters to make non-identifiable models provably identifiable

Mohamed Tarek

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Abstract

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Identifiability

Make models great again by optimally restricting parameters to make non-identifiable models provably identifiable

Mohamed Tarek

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Publication

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X-linked hypophosphatemia (XLH)

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Pharmacodynamic Exposure–Response Analysis of Fracture Count Data

Pharmacodynamic Exposure–Response Analysis of Fracture Count Data Following Treatment with Burosumab in Patients with XLH

Krina Mehta, Jose Storopoli, Nikita Ramwani, Emilia Quattrocchi, Joga Gobburu, Thomas Weber, Matthew W. Hruska, Douglas Marsteller

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Publication

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Infectious Diseases

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Population pharmacokinetics of ciprofloxacin in newborns with early onset neonatal sepsis and suspected meningitis

Garg, Kunal; Bhandari, Ritika Kondel; Shafiq, Nusrat; Jain, Suksham; Jaswal, Shivani; Chawla, Deepak; Mallayasamy, Surulivelrajan; Khurana, Supreet; Batcha, Jaya Shree Dilli;

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Publication

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Oncology

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Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients

Batcha, Jaya Shree Dilli; Gota, Vikram; Matcha, Saikumar; Raju, Arun Prasath; Rao, Mahadev; Udupa, Karthik S; Mallayasamy, Surulivelrajan;

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Poster

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Neurology, Pain

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Safety, Tolerability, and Pharmacokinetics of BHV-2100, a First-in-Class TRPM3 Antagonist for Pain

Volkan Granit, Richard Bertz, Andrew Lucas, Eric Ashbrenner, Mary Donohue, Patricia Mydlow, Christopher Jensen, Joris Vriens, Thomas Voets, Beth Emerson, Irfan Qureshi, Vladimir Coric

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Publication

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mRNA, FIH

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Translational Kinetic-Pharmacodynamics of mRNA-6231, an Investigational mRNA Therapeutic Encoding Mutein Interleukin-2

Ivana Liric Rajlic, Beatriz Guglieri-Lopez, Nabeel Rangoonwala, Vijay Ivaturi, Linh Van, Simone Mori, Brian Wipke, Douglas Burdette, Husain Attarwala

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Publication

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Visual predictive check of longitudinal models and dropout

Chuanpu Hu, Anna G. Kondic, Amit Roy

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Publication

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MIDD, Pediatrics

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Bioequivalence Study Followed by Model Informed Dose Optimization of a Powder for Oral Suspension of 6-Mercaptopurine.

Bhavatharini P A, Mahendra Joshi, Archana Kakkar, Ivaturi V, et al.

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Publication

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Bayesian

A Complete Bayesian Workflow in Pumas

Mohamed Tarek (1,2), Jose Storopoli (1,3), Casey Davis (4), Chris Elrod (1,5), Vijay Ivaturi (1,6)

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Publication

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IVIVC

A convolution-based in vitro-in vivo correlation model for methylphenidate hydrochloride delayed-release and extended-release capsule

Pawan Kumar Gupta, Bev Incledon, Jogarao V. S. Gobburu, Roberto Gomeni

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Publication

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Cardio Vascular

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A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass

Erik R. Strauss, Shuhui Li, Reney Henderson, Ross Carpenter, Dong Guo, Kiruphagaran Thangaraju, Upendra Katneni, Paul W. Buehler, Jogarao V.S. Gobburu, Kenichi A. Tanaka

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Publication

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Bayesian

A Practitioner's Guide to Bayesian Inference in Pharmacometrics using Pumas

Mohamed Tarek, Jose Storopoli, Casey Davis, Chris Elrod, Julius Krumbiegel, Chris Rackauckas, Vijay Ivaturi

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Publication

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Infectious Disease, Pediatrics

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Bayesian

Bayesian model-guided antimicrobial therapy in pediatrics. Front Pharmacol.

Bunn HT, Gobburu JVS, Floryance LM

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Poster

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Diabetes

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Comparison of Pumas and NONMEM in parameter estimation of a complex pharmacodynamic model

Zhengqi Tan (1), Ayyappa Chaturvedula (1), Julie Desrochers (2), Kirsten Riber Bergmann (2), Yassine Kamal Lyauk (2), Rune Viig Overgaard (2)

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Poster

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DeepNLME

DeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes

Niklas Korsbo, Mohamed Tarek, Chris Elrod, Antoine Soubret, Francesco Brizzi, Christopher Rackauckas, Jogarao Gobburu, Vijay Ivaturi

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Publication

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Oncology

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Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions. Cancer Chemother Pharmacol.

Beumer JH, Kennard BC, Holleran JL, Moore N, Zlott J, Miller BM, Kummar S, Chen A, Doroshow J, Park W, Gobburu J, Dunn A

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Poster

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Bayesian

Fast cross-validation for Bayesian inference using proposals on a linear subspace

Mohamed Tarek [1, 2], Many Francis [3], Anastasios Panagiotelis [2]

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Poster

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Bayesian

Marginal Markov Chain Monte Carlo (MCMC)

Mohamed Tarek, Jose Storopoli, Chris Elrod, Joga Gobbur, Vijay Ivaturi

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Poster

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Bayesian

Marginal No-U-Turn Sampler for Bayesian Analysis in Pharmacometrics

Mohamed Tarek [1, 2], ose Storopoli [1, 3], Chris Elrod [1, 4], Joga Gobburu [1, 5], Vijay Ivaturi [1, 5]

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Publication

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Model-based approach to identify predictors of paclitaxel-induced myelosuppression in “real-world” administration. CPT Pharmacometrics Syst Pharmacol.

Salem, AM, Dvergsten, E, Karovic, S, Maitland, ML, Gopalakrishnan, M

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Poster

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NLME

On the error of the Laplace approximation when lags and duration parameters have between-subject variation

Andreas Noack, Patrick Kofod Mogensen, Vijay Ivaturi

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Publication

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Infectious Disease

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Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling.

Jarugula P, Akcan-Arikan A, Munoz-Rivas F, Moffett BS, Ivaturi V, Rios D

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Publication

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Pediatric

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Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia.

Matcha, S., Raj, E.A., Mahadevan, R., et al.

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Publication

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Infectious Diseases, Pediatric

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Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates

Saikumar Matcha, Jayashree Dillibatcha, Arun Prasath Raju, Bhim Bahadur Chaudhari, Sudheer Moorkoth, Leslie E. Lewis, Surulivelrajan Mallayasamy

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Publication

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Rare Disorders

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Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia.

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

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Poster

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Burosumab Treatment - Induced Increases Serum Phosphate Are associated with Reduction in Fracture Counts in Adults with X-Linked Hypophosphatemia

Jose Storopoli, Nikita Ramwani, Emilia Quattrocchi, Joga Gobburu, Matthew Hruska, Douglas Marsteller

/images/pumasai/solution-icons/pumas.png

Poster

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Bayesian

A Full Bayesian Approach for Population Pharmacokinetic/Pharmacodynamic Modeling of Unfractionated Heparin in Pediatrics.

Salem AM, Moffett BS, Gopalakrishnan M

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Poster

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Machine Learning

Application of Machine Learning Analysis to Inform Medical Countermeasure Development – A Case Study Using Random Forest Ensemble to Identify Predictive Biomarkers of Mortality for Hematopoietic Acute Radiation Syndrome and Confirmation of Benefit with Leukine® Across Myeloid Lineages

Goyal RK, McManus JL, Gopalakrishnan M

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Poster

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Vaccines

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Immunostimulatory/Immunodynamic Model of an mRNA-Based Vaccine Against Cytomegalovirus Infection to Guide Vaccine Dose Selection

Greene S, Attarwala H, Ivaturi V, Guglieri-Lopez B, Kramarczyk JF, Panther L, Natenshon, A

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Publication

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Infectious Disease, Tuberculosis

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Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children

Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK

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Publication

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BMT

Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation.

Li, S., Dvorak, C.C., Lu, Y., Chan, D., Gobburu, J.V.S., Long-Boyle, J. and Apsel Winger, B.

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Publication

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Infectious Disease

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Population Pharmacokinetics of Vancomycin in Pregnant Women.

Goyal RK, Moffett BS, Gobburu JVS, Al Mohajer M

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Publication

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Metabolic Disorder

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Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

/images/pumasai/solution-icons/pumas.png

Publication

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Infectious Disease

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Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India

Jeffrey Pradeep Raj, Nithya Jaideep Gogtay, Avaneesh Pandey, Ashish Kumar Kakkar, Nusrat Shafiq, Padmaja Mekala, Usharani Pingali, Arun Prasath Raju, Surulivelrajan Mallayasamy, Nilima Arun Kshirsagar

/images/pumasai/solution-icons/pumas.png

Poster

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SAEM, NLME

SAEM in Pumas – A systematic evaluation and benchmarking

Chris Elrod, Andreas Noack, Patrick Kofod Mogensen, Vaibhav Dixit, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png

Poster

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NLME

Analysis of Laplace Approximation for Pharmaceutical Nonlinear Mixed Effects Models

Mohamed Tarek, Christopher Rackauckas, Patrick K. Mognesen, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/deeppumas.png

Poster

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DeepNLME, Bayesian

Bayesian Neural Ordinary Differential Equations

Raj Dandekar, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia Valadez, Chris Rackauckas

/images/pumasai/solution-icons/pumas.png

Poster

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NLME

Generalized FOCE with Pumas

Andreas Noack, Patrick Kofod Mogensen, Joakim Nyberg, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png

Poster

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NLME

Non-Gaussian random effects in nonlinear mixed effects models in Pumas

Mohamed Tarek, Vijay Ivaturi, Andreas Noack

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Poster

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Optimal Design

Nonlinear mixed effects model based optimal design of experiments using mathematical programming in Pumas

Mohamed Tarek, Joakim Nyberg, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png

Poster

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Bayesian

Parallel hierarchical Gibbs-NUTS MCMC algorithm for Nonlinear Mixed Effects models in Pumas

Mohamed Tarek, Manu Francis, Vijay Ivaturi

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Publication

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Epilepsy

A Prospective, Real-World, Clinical Pharmacokinetic Study to Inform Lacosamide Dosing in Critically Ill Patients Undergoing Continuous Venovenous Haemofiltration (PADRE-02).

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

/images/pumasai/solution-icons/pumas.png

Poster

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Bayesian

Subspace MCMC algorithm for Bayesian parameter estimation of hierarchical PK/PD models in Pumas

Manu Francis, Vijay Ivaturi, Mohamed Tarek

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Publication

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Automatic Differentiation

Generalizing Automatic Differentiation to Automatic Sparsity, Uncertainty, Stability, and Parallelism

Rackauckas C

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Publication

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Differential Equations

ModelingToolkit: A Composable Graph Transformation System For Equation-Based Modeling

Yingbo Ma, Shashi Gowda, Ranjan Anantharaman, Chris Laughman, Viral Shah, Chris Rackauckas

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Publication

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Cardio Vascular

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Population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant patent ductus arteriosus

Kannan Sridharan, Eman Al Ansari, Mwila Mulubwa, Arun Prasath Raju, Abdulraoof Al Madhoob, Muna Al Jufairi, Zakariya Hubail, Reem Al Marzooq, Sadeq Jaafar Radhi Hasan, Surulivelrajan Mallaysamy

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Publication

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DeepNLME, Bayesian, NLME

Bayesian Neural Ordinary Differential Equations

Raj Dandekar, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia Valadez, Chris Rackauckas

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Publication

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BMT

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Characterization of Drug-Drug Interactions on the Pharmacokinetic Disposition of Busulfan in the Pediatric Hematopoietic Stem Cell Transplantation Patient

Dunn A, Ivaturi V, Paek H, Gillespie A, Brady Moffett, Gobburu J, Krance R

/images/pumasai/solution-icons/pumas.png

Publication

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Population Pharmacokinetic Modeling of Belinostat and its Major Metabolite in Advanced Cancer Patients with varying degrees of Liver Dysfunction

Sumar A, Takebe N, Chen A, Kummar S, Piekarz R, Kiesel B, Moore N, Doroshow J, Beumer J, Gobburu J

/images/pumasai/solution-icons/pumas.png

Publication

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A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass

Strauss, Erik R, Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S. Gammie

/images/pumasai/solution-icons/pumas.png

Publication

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Epilepsy

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A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01)

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

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Publication

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NLME, NCA,BE, PBPK

Accelerated Predictive Healthcare Analytics with Pumas, a High Performance Pharmaceutical Modeling and Simulation Platform

Rackauckas, Chris, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Simon Byrne, Shubham Maddhashiya, et al.

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Publication

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Application of a Plasmin Generation Assay to Define Pharmacodynamic Effects of Tranexamic Acid in Women Undergoing Cesarean Delivery

Adam Miszta, Homa K. Ahmadzia, Naomi L. C. Luban, Shuhui Li, Dong Guo, Lori A. Holle, Jeffrey S. Berger

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Publication

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Uncertainity Quantification

Bayesian-Koopman Techniques for Optimization of Intervention with Respect to Uncertainty in PuMaS.jl.

Rackauckas C, Ivaturi V

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Poster

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Optimal Design

Fast evaluation of experimental designs in non-linear mixed effects models with the PuMaS package.

Noack A, Ivaturi V, Nyberg J

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Publication

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BMT

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Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation

Hechuan Wang, Aksana K. Jones, Christopher C. Dvorak, Liusheng Huang, Paul Orchard, Vijay Ivaturi, Janel Long-Boyle

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Publication

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BMT

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Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients

Vijay Ivaturi, Christopher C. Dvorak, Danna Chan, Tao Liu, Morton J. Cowan, Justin Wahlstrom, Melisa Stricherz, Cathryn Jennissen, Paul J. Orchard, Jakub Tolar, Sung-Yun Pai, Liusheng Huang, Francesca Aweeka, Janel Long-Boyle

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Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
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Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
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