Publications

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Abstract

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Oncology

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DeepNLME

A DeepNLME-based Tumor Growth Dynamics and Overall Survival Model for Non Small Cell Lung Cancer

Mohamed Tarek, Lorenzo Contento, Amit Roy, Kiran Gauthier, Anna Kondic, Jun Shen

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Poster

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Oncology

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DeepNLME

A DeepNLME-based Tumor Growth Dynamics and Overall Survival Model for Non Small Cell Lung Cancer,

Mohamed Tarek, Lorenzo Contento, Amit Roy, Kiran Gauthier, Anna Kondic, Jun Shen

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Publication

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Complex Covariates

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DeepLearning

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Poster

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DeepNLME, Images

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Abstract

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DeepNLME, Images

A Framework for Evaluating Predictive Models Using Synthetic Image Covariates and Longitudinal Data

Simon Deltadahl, Andreu Vall, Vijay Ivaturi, Niklas Korsbo

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Publication

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Oncology

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A Model-Informed Drug Development Approach to Design a Phase 3 Trial of Teverelix Drug Product in Advanced Prostate Cancer Patients with Increased Cardiovascular Risk

Chenna Keshava Reddy Sannala, Carol MacLean, Finn Larsen, Steve van Os, Pravin Jadhav, Neal Shore, Alicia K. Morgans, Tochukwu Okwuosa, Joga Gobburu

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Poster

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Oncology

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DeepNLME

A Neural Networks-assisted NLME Framework: Case Study on Modeling Platelet Counts

Reza Najafi Zare, David Busse, Ida Neldemo, Alejandro Perez Pitarch, Lena E. Friberg, Ali Farnoud

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Publication

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DeepNLME

Artificial Intelligence and Disease Modeling: Focus on Neurological Disorders

Gennaro Pagano, Niklas Korsbo, Vijay Ivaturi, Antoine Soubret

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Podium

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Bayesian NLME

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Bayesian inference of pharmaceutical models with Pumas - A showcase of Julia for high performance interactive computing

David Widmann

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Publication

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MIEE

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Bioequivalence study followed by model-informed dose optimization of a powder for oral suspension of 6-mercaptopurine

Bhavatharini Arun, Mahendra Joshi, Archana Khosa Kakkar, Shivkumar Madki, Vijay Ivaturi, Girish Chinnaswamy, Shripad Banavali, Vikram Gota

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Podium

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Ophthalmology, Longitudinal biomarkers

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DeepNLME

Charting New Paths In Ophthalmology With DeepNLME-Powered Predictive Modeling​

Niklas Korsbo

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Abstract

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Oncology

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DeepNLME

Data-Driven Discovery of Feedback Mechanisms in Acute Myeloid Leukaemia

Carl Julius Martensen, Niklas Korsbo, Sebastian Sager, Vijay Ivaturi

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Publication

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DeepNLME, Symbolic Regression

Data-Driven Discovery of Feedback Mechanisms in Acute Myeloid Leukaemia: Alternatives to classical models using Deep Nonlinear Mixed Effect modeling and Symbolic Regression

Carl Julius Martensen, Niklas Korsbo, Vijay Ivaturi, Sebastian Sager

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Poster

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Oncology

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DeepNLME

Data-Driven Discovery of Feedback Mechanisms in Acute Myeloid Leukaemia

Carl Julius Martensen, Niklas Korsbo, Vijay Ivaturi, Sebastian Sager

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Poster

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Myelofibrosis Anemia

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PKPD modeling

Development of a pharmacokinetic-pharmacodynamic model to describe blood hepcidin levels in patients with myelofibrosis and assess target engagement of zilurgisertib, an ALK2 inhibitor

Ikhlas Guermi, Beatriz Guglieri-Lopez, Phil Wang, Betty Lamothe, Amanda McBride, Jennifer Sheng, Xuejun Chen, Yan-ou Yang

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Abstract

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Myelofibrosis Anemia

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PKPD modeling

Development of a pharmacokinetic-pharmacodynamic model to describe blood hepcidin levels in patients with myelofibrosis and assess target engagement of zilurgisertib, an ALK2 inhibitor

Ikhlas Guermi, Beatriz Guglieri-Lopez, Phil Wang, Betty Lamothe, Amanda McBride, Jennifer Sheng, Xuejun Chen, Yan-ou Yang

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Publication

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Infectious Diseases

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PBPK

Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures

Sanjay Jain, Xueyi Chen, Bhavatharini Arun, Oscar Nino Meza, Mona Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth Tucker, Laurence Carroll, Joel Freundlich, Charles Peloquin, Vijay Ivaturi

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Poster

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Evaluation of Large Language Models for an AI Chat Assistant Focused on Pumas and Pharmacometrics

Agastya Deepak Vinchhi, Juan José González Oneto, Vijay Ivaturi

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Publication

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Generic Drug Development

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Exploration of the potential impact of batch-to-batch variability on the establishment of pharmacokinetic bioequivalence for inhalation powder drug products

Shuhui Li, Kairui Feng, Jieon Lee, Yuqing Gong, Fang Wu2, Bryan Newman, Miyoung Yoon, Lanyan Fang, Liang Zhao, Jogarao V. S. Gobburu

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Poster

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Attention deficit hyperactivity disorder ( ADHD) in adults

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Exposure-Efficacy and Exposure-Safety analyses

Exposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder

Yanlin Wang, Asma Baliouze, Mélanie Wilbaux, Viki Cotero-Lefevre, Susan Shoaf, Osman Turkoglu, Joga Gobburu, Xiaofeng Wang

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Abstract

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Exposure-Response Analysis of Centanafadine Sustained Release Tablets in Adults with Attention-Deficit/Hyperactivity Disorder

Yanlin Wang, Asma Baliouze, Mélanie Wilbaux, Viki Cotero-Lefevre, Susan Shoaf, Osman Turkoglu, Joga Gobburu, Xiaofeng Wang

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Poster

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PopPK modeling in new settings (e.g. indication, population)

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PopPK Regulatory submission

How to handle population pharmacokinetics modeling in the context of a regulatory submission for a compound already well-characterized in other settings? A case-study with nivolumab in urothelial cancer

Mélanie Wilbaux, Yue Zhao, Anna Kondic, Lora Hamuro, Amit Roy

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Abstract

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PopPK modeling in new settings (e.g. indication, population)

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PopPK Regulatory submission

How to handle population pharmacokinetics modeling in the context of a regulatory submission for a compound already well-characterized in other settings? A case-study with nivolumab in urothelial cancer.

Mélanie Wilbaux, Yue Zhao, Anna Kondic, Lora Hamuro, Amit Roy

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Publication

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Vaccines

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Immunostimulatory/Immunodynamic model of mRNA-1273 to guide pediatric vaccine dose selection

Vijay Ivaturi, Husain Attarwala, Weiping Deng, Baoyu Ding, Sabine Schnyder Ghamloush, Bethany Girard, Javid Iqbal, Saugandhika Minnikanti, Honghong Zhou, Jacqueline Miller, Rituparna Das

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Podium

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Improvement of simulation performance and VPCs in a model for a drug with a complex absorption profile

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Non-parametric fitting of the distribution of the random effects using a normalizing flow

Improving simulations by learning the true random effects' distribution from a population using generative machine learning

Lorenzo Contento

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Abstract

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DeepNLME

Improving simulations by learning the true random effects' distribution from a population using generative machine learning

Lorenzo Contento, Mohamed Tarek

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Podium

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Identifiability

Make models great again by optimally restricting parameters to make non-identifiable models provably identifiable

Mohamed Tarek

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Abstract

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Identifiability

Make models great again by optimally restricting parameters to make non-identifiable models provably identifiable

Mohamed Tarek

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Publication

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X-linked hypophosphatemia (XLH)

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Pharmacodynamic Exposure–Response Analysis of Fracture Count Data

Pharmacodynamic Exposure–Response Analysis of Fracture Count Data Following Treatment with Burosumab in Patients with XLH

Krina Mehta, Jose Storopoli, Nikita Ramwani, Emilia Quattrocchi, Joga Gobburu, Thomas Weber, Matthew W. Hruska, Douglas Marsteller

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Abstract

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MIPD

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Pharmacokinetic Model-guided Enoxaparin Dosing in the NICU: Retrospective Analysis to Plan for Prospective Feasibility Trial

Tamorah Lewis, Vijay Ivaturri, Catherine Schentag, Leonardo Brandao, Haden Bunn

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Poster

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MIPD

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Pharmacokinetic Model-guided Enoxaparin Dosing in the NICU: Retrospective Analysis to Plan for Prospective Feasibility Trial

Tamorah Lewis, Vijay Ivaturri, Catherine Schentag, Leonardo Brandao, Haden Bunn

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Publication

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Pharmacokinetic model‐guided enoxaparin dosing in the Neonatal ICU: Retrospective cohort study to plan for prospective feasibility trial

Haden Bunn, Catherine Schentag, Leonardo R. Brandão, Vijay Ivaturi, Tamorah Lewis

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Publication

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Infectious Diseases

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Population pharmacokinetics of ciprofloxacin in newborns with early onset neonatal sepsis and suspected meningitis

Garg, Kunal; Bhandari, Ritika Kondel; Shafiq, Nusrat; Jain, Suksham; Jaswal, Shivani; Chawla, Deepak; Mallayasamy, Surulivelrajan; Khurana, Supreet; Batcha, Jaya Shree Dilli;

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Publication

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Oncology

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Predictive performance of population pharmacokinetic models of imatinib in chronic myeloid leukemia patients

Batcha, Jaya Shree Dilli; Gota, Vikram; Matcha, Saikumar; Raju, Arun Prasath; Rao, Mahadev; Udupa, Karthik S; Mallayasamy, Surulivelrajan;

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Publication

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Operations

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Scalable Optimal Transport Methods in Machine Learning: A Contemporary Survey

Abdelwahed Khamis, Russell Tsuchida, Mohamed Tarek, Vivien Rolland, Lars Petersson

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Abstract

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Psychiatry

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Switching Patients With Schizophrenia From Intramuscular Paliperidone Palmitate Once Monthly to TV-46000, a Long-Acting Subcutaneous Antipsychotic: An Exploration of Population Pharmacokinetic-Based Strategies

I. Perlstein, J. Meyer, Z. Yue, J. Owen, J. Storopoli, V. Ivaturi, K.R. Franzenburg, M. Suett, R. Hansen, A. Merenlender Wagner, R. Singh

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Poster

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Psychiatry

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Switching Patients With Schizophrenia From Intramuscular Paliperidone Palmitate Once Monthly to TV-46000, a Long-Acting Subcutaneous Antipsychotic: An Exploration of Population Pharmacokinetic-Based Strategies

Itay Perlstein, Jonathan Meyer, Ziqi Yue, Joel Owen, Jose Storopoli, Vijay Ivaturi, Kelli R Franzenburg, Mark Suett, Rolf Hansen, Avia Merenlender Wagner, Rajendra Singh

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Abstract

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Psychiatry

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Switching Patients With Schizophrenia to TV-46000, a Long Acting Subcutaneous Antipsychotic, From Risperidone Microspheres: An Exploration of Population Pharmacokinetic - Based Strategies

Jonathan Meyer, Itay Perlstein, Ziqi Yue, Joel Owen, Vijay Ivaturi, Kelli Franzenburg, Mark Suett, Rolf Hansen, Avia Merenlender Wagner, Rajendra Singh

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Poster

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Psychiatry

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Switching Patients With Schizophrenia to TV-46000, a Long Acting Subcutaneous Antipsychotic, From Risperidone Microspheres: An Exploration of Population Pharmacokinetic - Based Strategies

Itay Perlstein, Jonathan Meyer, Ziqi Yue, Joel Owen, Jose Storopoli, Vijay Ivaturi, Kelli R Franzenburg, Mark Suett, Rolf Hansen, Avia Merenlender Wagner, Rajendra Singh

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Publication

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mRNA, FIH

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Translational Kinetic-Pharmacodynamics of mRNA-6231, an Investigational mRNA Therapeutic Encoding Mutein Interleukin-2

Ivana Liric Rajlic, Beatriz Guglieri-Lopez, Nabeel Rangoonwala, Vijay Ivaturi, Linh Van, Simone Mori, Brian Wipke, Douglas Burdette, Husain Attarwala

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Publication

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MIDD, Nephrology, Pediatrics

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Urine Osmolality Is a Potential Marker of Longer-Term Efficacy of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis

Ivaturi, Vijay; Gobburu, Joga; Leslie, Bruce; Wang, Xiaofeng; Jadhav, Pravin

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Publication

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Visual predictive check of longitudinal models and dropout

Chuanpu Hu, Anna G. Kondic, Amit Roy

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Publication

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MIDD, Pediatrics

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“Bioequivalence Study Followed by Model Informed Dose Optimization of a Powder for Oral Suspension of 6-Mercaptopurine.”

Bhavatharini P A, Mahendra Joshi, Archana Kakkar, Ivaturi V, et al.

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Poster

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Bayesian

A Complete Bayesian Workflow in Pumas

Mohamed Tarek (1,2), Jose Storopoli (1,3), Casey Davis (4), Chris Elrod (1,5), Vijay Ivaturi (1,6)

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Publication

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IVIVC

A convolution-based in vitro-in vivo correlation model for methylphenidate hydrochloride delayed-release and extended-release capsule

Pawan Kumar Gupta, Bev Incledon, Jogarao V. S. Gobburu, Roberto Gomeni

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Publication

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Cardio Vascular

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“A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass”

Erik R. Strauss, Shuhui Li, Reney Henderson, Ross Carpenter, Dong Guo, Kiruphagaran Thangaraju, Upendra Katneni, Paul W. Buehler, Jogarao V.S. Gobburu, Kenichi A. Tanaka

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Publication

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Bayesian

A Practitioner's Guide to Bayesian Inference in Pharmacometrics using Pumas

Mohamed Tarek, Jose Storopoli, Casey Davis, Chris Elrod, Julius Krumbiegel, Chris Rackauckas, Vijay Ivaturi

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Publication

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Infectious Disease, Pediatrics

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Bayesian

“Bayesian model-guided antimicrobial therapy in pediatrics. Front Pharmacol.”

Bunn HT, Gobburu JVS, Floryance LM

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Publication

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Infectious Disease

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Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study. Antibiotics.

Selig DJ, Kress AT, Nadeau RJ, DeLuca JP

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Poster

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Diabetes

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“Comparison of Pumas and NONMEM in parameter estimation of a complex pharmacodynamic model”

Zhengqi Tan (1), Ayyappa Chaturvedula (1), Julie Desrochers (2), Kirsten Riber Bergmann (2), Yassine Kamal Lyauk (2), Rune Viig Overgaard (2)

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Poster

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DeepNLME

“DeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes”

Niklas Korsbo, Mohamed Tarek, Chris Elrod, Antoine Soubret, Francesco Brizzi, Christopher Rackauckas, Jogarao Gobburu, Vijay Ivaturi

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Publication

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Oncology

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“Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions. Cancer Chemother Pharmacol.”

Beumer JH, Kennard BC, Holleran JL, Moore N, Zlott J, Miller BM, Kummar S, Chen A, Doroshow J, Park W, Gobburu J, Dunn A

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Poster

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Bayesian

“Fast cross-validation for Bayesian inference using proposals on a linear subspace”

Mohamed Tarek [1, 2], Many Francis [3], Anastasios Panagiotelis [2]

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Poster

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Bayesian

“Marginal No-U-Turn Sampler for Bayesian Analysis in Pharmacometrics”

Mohamed Tarek [1, 2], ose Storopoli [1, 3], Chris Elrod [1, 4], Joga Gobburu [1, 5], Vijay Ivaturi [1, 5]

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Publication

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“Model-based approach to identify predictors of paclitaxel-induced myelosuppression in “real-world” administration. CPT Pharmacometrics Syst Pharmacol.”

Salem, AM, Dvergsten, E, Karovic, S, Maitland, ML, Gopalakrishnan, M

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Poster

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NLME

“On the error of the Laplace approximation when lags and duration parameters have between-subject variation”

Andreas Noack, Patrick Kofod Mogensen, Vijay Ivaturi

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Publication

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Infectious Disease

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“Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling.”

Jarugula P, Akcan-Arikan A, Munoz-Rivas F, Moffett BS, Ivaturi V, Rios D

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Publication

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Pediatric

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“Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia.”

Matcha, S., Raj, E.A., Mahadevan, R., et al.

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Publication

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Infectious Diseases, Pediatric

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“Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates”

Saikumar Matcha, Jayashree Dillibatcha, Arun Prasath Raju, Bhim Bahadur Chaudhari, Sudheer Moorkoth, Leslie E. Lewis, Surulivelrajan Mallayasamy

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Publication

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Rare Disorders

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“Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia. “

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

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Poster

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Bayesian

“A Full Bayesian Approach for Population Pharmacokinetic/Pharmacodynamic Modeling of Unfractionated Heparin in Pediatrics.”

Salem AM, Moffett BS, Gopalakrishnan M

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Poster

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Machine Learning

“Application of Machine Learning Analysis to Inform Medical Countermeasure Development – A Case Study Using Random Forest Ensemble to Identify Predictive Biomarkers of Mortality for Hematopoietic Acute Radiation Syndrome and Confirmation of Benefit with Leukine® Across Myeloid Lineages”

Goyal RK, McManus JL, Gopalakrishnan M

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Poster

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Vaccines

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“Immunostimulatory/Immunodynamic Model of an mRNA-Based Vaccine Against Cytomegalovirus Infection to Guide Vaccine Dose Selection”

Greene S, Attarwala H, Ivaturi V, Guglieri-Lopez B, Kramarczyk JF, Panther L, Natenshon, A

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Publication

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Infectious Disease, Tuberculosis

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“Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children”

Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK

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Publication

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BMT

“Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation.”

Li, S., Dvorak, C.C., Lu, Y., Chan, D., Gobburu, J.V.S., Long-Boyle, J. and Apsel Winger, B.

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Publication

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Infectious Disease

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“Population Pharmacokinetics of Vancomycin in Pregnant Women.”

Goyal RK, Moffett BS, Gobburu JVS, Al Mohajer M

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Poster

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QSP

Pumas-QSP: A high-performance and easy-to-use modeling tool for Advanced Pharmaceutical Sciences

Roesch E, Jain A, Micluta-Campeanu S, Rackauckas C

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Publication

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Metabolic Disorder

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“Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia”

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

/images/pumasai/solution-icons/pumas.png

Publication

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Infectious Disease

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Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India

Jeffrey Pradeep Raj, Nithya Jaideep Gogtay, Avaneesh Pandey, Ashish Kumar Kakkar, Nusrat Shafiq, Padmaja Mekala, Usharani Pingali, Arun Prasath Raju, Surulivelrajan Mallayasamy, Nilima Arun Kshirsagar

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Poster

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SAEM, NLME

“SAEM in Pumas – A systematic evaluation and benchmarking”

Chris Elrod, Andreas Noack, Patrick Kofod Mogensen, Vaibhav Dixit, Vijay Ivaturi

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Poster

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NLME

“Analysis of Laplace Approximation for Pharmaceutical Nonlinear Mixed Effects Models”

Mohamed Tarek, Christopher Rackauckas, Patrick K. Mognesen, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/deeppumas.png

Poster

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DeepNLME, Bayesian

“Bayesian Neural Ordinary Differential Equations”

Raj Dandekar, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia Valadez, Chris Rackauckas

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Publication

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Automatic Differentiation

“Generalizing Automatic Differentiation to Automatic Sparsity, Uncertainty, Stability, and Parallelism,”

Rackauckas, C.

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Publication

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Differential Equations

ModelingToolkit: A Composable Graph Transformation System For Equation-Based Modeling.

Ma, Yingbo, Shashi Gowda, Ranjan Anantharaman, Chris Laughman, Viral Shah, Chris Rackauckas

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Poster

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NLME

“Non-Gaussian random effects in nonlinear mixed effects models in Pumas”

Mohamed Tarek, Vijay Ivaturi, Andreas Noack

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Poster

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Optimal Design

“Nonlinear mixed effects model based optimal design of experiments using mathematical programming in Pumas”

Mohamed Tarek, Joakim Nyberg, Vijay Ivaturi, Andreas Noack

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Publication

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DeepNLME

Opening the Blackbox: Accelerating Neural Differential Equations by Regularizing Internal Solver Heuristics.

Pal, Avik, Yingbo Ma, Viral Shah, Christopher Rackauckas

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Poster

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Bayesian

“Parallel hierarchical Gibbs-NUTS MCMC algorithm for Nonlinear Mixed Effects models in Pumas”

Mohamed Tarek, Manu Francis, Vijay Ivaturi

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Publication

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Epilepsy

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“A Prospective, Real-World, Clinical Pharmacokinetic Study to Inform Lacosamide Dosing in Critically Ill Patients Undergoing Continuous Venovenous Haemofiltration (PADRE-02).”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

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Poster

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Bayesian

“Subspace MCMC algorithm for Bayesian parameter estimation of hierarchical PK/PD models in Pumas”

Manu Francis, Vijay Ivaturi, Mohamed Tarek

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Publication

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Precision Dosing

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Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software

Praneeth Jarugula, Sarah Scott, Vijay Ivaturi, Andreas Noack, Brady S. Moffet, Adnan Bhutta, Jogarao V.S. Gobburu

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Publication

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Cardio Vascular

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Population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant patent ductus arteriosus

Kannan Sridharan, Eman Al Ansari, Mwila Mulubwa, Arun Prasath Raju, Abdulraoof Al Madhoob, Muna Al Jufairi, Zakariya Hubail, Reem Al Marzooq, Sadeq Jaafar Radhi Hasan, Surulivelrajan Mallaysamy

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Publication

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“A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass.”

Strauss, Erik R., Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S. Gammie, et al.

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Publication

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Epilepsy

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“A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01).”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

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Publication

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NLME, NCA,BE, PBPK

“Accelerated Predictive Healthcare Analytics with Pumas, a High Performance Pharmaceutical Modeling and Simulation Platform.”

Rackauckas, Chris, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Simon Byrne, Shubham Maddhashiya, et al.

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Publication

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“Application of a Plasmin Generation Assay to Define Pharmacodynamic Effects of Tranexamic Acid in Women Undergoing Cesarean Delivery.”

Miszta, Adam, Homa K. Ahmadzia, Naomi L. C. Luban, Shuhui Li, Dong Guo, Lori A. Holle, Jeffrey S. Berger, et al.

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Publication

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Bayesian, DeepNLME, NLME

“Bayesian Neural Ordinary Differential Equations,”

Dandekar, Raj, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia-Valadez, Chris Rackauckas

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Publication

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BMT

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Characterization of Drug-Drug Interactions on the Pharmacokinetic Disposition of Busulfan in the Pediatric Hematopoietic Stem Cell Transplantation Patient

Dunn A, Ivaturi V, Paek H, Gillespie A, Brady Moffett, Gobburu J, Krance R

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Publication

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Population Pharmacokinetic Modeling of Belinostat and its Major Metabolite in Advanced Cancer Patients with varying degrees of Liver Dysfunction

Sumar A, Takebe N, Chen A, Kummar S, Piekarz R, Kiesel B, Moore N, Doroshow J, Beumer J, Gobburu J

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Publication

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BMT

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“Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation”

Hechuan Wang, Aksana K. Jones, Christopher C. Dvorak, Liusheng Huang, Paul Orchard, Vijay Ivaturi, Janel Long-Boyle

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Publication

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BMT

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“Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients”

Vijay Ivaturi, Christopher C. Dvorak, Danna Chan, Tao Liu, Morton J. Cowan, Justin Wahlstrom, Melisa Stricherz, Cathryn Jennissen, Paul J. Orchard, Jakub Tolar, Sung-Yun Pai, Liusheng Huang, Francesca Aweeka, Janel Long-Boyle

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Publication

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Precision Dosing

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The time is now: model-based dosing to optimize drug therapy

Danna Chan, Vijay Ivaturi, Janel Long-Boyle

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Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
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Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
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