Publications

2023

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Publication

|

MIDD, Pediatrics

|

“Bioequivalence Study Followed by Model Informed Dose Optimization of a Powder for Oral Suspension of 6-Mercaptopurine.”

Bhavatharini P A, Mahendra Joshi, Archana Kakkar, Ivaturi V, et al.

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

A Complete Bayesian Workflow in Pumas

Mohamed Tarek (1,2), Jose Storopoli (1,3), Casey Davis (4), Chris Elrod (1,5), Vijay Ivaturi (1,6)

/images/pumasai/solution-icons/pumas.png

Publication

|

|

IVIVC

A convolution-based in vitro-in vivo correlation model for methylphenidate hydrochloride delayed-release and extended-release capsule

Pawan Kumar Gupta, Bev Incledon, Jogarao V. S. Gobburu, Roberto Gomeni

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Publication

|

Cardio Vascular

|

“A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass”

Erik R. Strauss, Shuhui Li, Reney Henderson, Ross Carpenter, Dong Guo, Kiruphagaran Thangaraju, Upendra Katneni, Paul W. Buehler, Jogarao V.S. Gobburu, Kenichi A. Tanaka

/images/pumasai/solution-icons/pumas.png

Publication

|

|

Bayesian

A Practitioner's Guide to Bayesian Inference in Pharmacometrics using Pumas

Mohamed Tarek, Jose Storopoli, Casey Davis, Chris Elrod, Julius Krumbiegel, Chris Rackauckas, Vijay Ivaturi

/images/pumasai/solution-icons/consulting.png

Publication

|

Infectious Disease, Pediatrics

|

Bayesian

“Bayesian model-guided antimicrobial therapy in pediatrics. Front Pharmacol.”

Bunn HT, Gobburu JVS, Floryance LM

/images/pumasai/solution-icons/consulting.png

Publication

|

Infectious Disease

|

Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study. Antibiotics.

Selig DJ, Kress AT, Nadeau RJ, DeLuca JP

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Poster

|

Diabetes

|

“Comparison of Pumas and NONMEM in parameter estimation of a complex pharmacodynamic model”

Zhengqi Tan (1), Ayyappa Chaturvedula (1), Julie Desrochers (2), Kirsten Riber Bergmann (2), Yassine Kamal Lyauk (2), Rune Viig Overgaard (2)

/images/pumasai/solution-icons/deeppumas.png

Poster

|

|

DeepNLME

“DeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes”

Niklas Korsbo, Mohamed Tarek, Chris Elrod, Antoine Soubret, Francesco Brizzi, Christopher Rackauckas, Jogarao Gobburu, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png

Publication

|

Oncology

|

“Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions. Cancer Chemother Pharmacol.”

Beumer JH, Kennard BC, Holleran JL, Moore N, Zlott J, Miller BM, Kummar S, Chen A, Doroshow J, Park W, Gobburu J, Dunn A

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

“Fast cross-validation for Bayesian inference using proposals on a linear subspace”

Mohamed Tarek [1, 2], Many Francis [3], Anastasios Panagiotelis [2]

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

“Marginal No-U-Turn Sampler for Bayesian Analysis in Pharmacometrics”

Mohamed Tarek [1, 2], ose Storopoli [1, 3], Chris Elrod [1, 4], Joga Gobburu [1, 5], Vijay Ivaturi [1, 5]

/images/pumasai/solution-icons/pumas.png

Publication

|

|

“Model-based approach to identify predictors of paclitaxel-induced myelosuppression in “real-world” administration. CPT Pharmacometrics Syst Pharmacol.”

Salem, AM, Dvergsten, E, Karovic, S, Maitland, ML, Gopalakrishnan, M

/images/pumasai/solution-icons/pumas.png

Poster

|

|

NLME

“On the error of the Laplace approximation when lags and duration parameters have between-subject variation”

Andreas Noack, Patrick Kofod Mogensen, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/lyv.png

Publication

|

Infectious Disease

|

“Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling.”

Jarugula P, Akcan-Arikan A, Munoz-Rivas F, Moffett BS, Ivaturi V, Rios D

/images/pumasai/solution-icons/pumas.png

Publication

|

Pediatric

|

“Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia.”

Matcha, S., Raj, E.A., Mahadevan, R., et al.

/images/pumasai/solution-icons/pumas.png

Publication

|

Infectious Diseases, Pediatric

|

“Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates”

Saikumar Matcha, Jayashree Dillibatcha, Arun Prasath Raju, Bhim Bahadur Chaudhari, Sudheer Moorkoth, Leslie E. Lewis, Surulivelrajan Mallayasamy

/images/pumasai/solution-icons/pumas.png

Publication

|

Rare Disorders

|

“Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia. “

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

“A Full Bayesian Approach for Population Pharmacokinetic/Pharmacodynamic Modeling of Unfractionated Heparin in Pediatrics.”

Salem AM, Moffett BS, Gopalakrishnan M

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Machine Learning

“Application of Machine Learning Analysis to Inform Medical Countermeasure Development – A Case Study Using Random Forest Ensemble to Identify Predictive Biomarkers of Mortality for Hematopoietic Acute Radiation Syndrome and Confirmation of Benefit with Leukine® Across Myeloid Lineages”

Goyal RK, McManus JL, Gopalakrishnan M

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Poster

|

Vaccines

|

“Immunostimulatory/Immunodynamic Model of an mRNA-Based Vaccine Against Cytomegalovirus Infection to Guide Vaccine Dose Selection”

Greene S, Attarwala H, Ivaturi V, Guglieri-Lopez B, Kramarczyk JF, Panther L, Natenshon, A

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Publication

|

Infectious Disease, Tuberculosis

|

“Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children”

Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Publication

|

|

BMT

“Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation.”

Li, S., Dvorak, C.C., Lu, Y., Chan, D., Gobburu, J.V.S., Long-Boyle, J. and Apsel Winger, B.

/images/pumasai/solution-icons/consulting.png/images/pumasai/solution-icons/pumas.png

Publication

|

Infectious Disease

|

“Population Pharmacokinetics of Vancomycin in Pregnant Women.”

Goyal RK, Moffett BS, Gobburu JVS, Al Mohajer M

/images/pumasai/solution-icons/pumas.png

Poster

|

|

QSP

Pumas-QSP: A high-performance and easy-to-use modeling tool for Advanced Pharmaceutical Sciences

Roesch E, Jain A, Micluta-Campeanu S, Rackauckas C

/images/pumasai/solution-icons/consulting.png

Publication

|

Metabolic Disorder

|

“Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia”

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn

/images/pumasai/solution-icons/pumas.png

Publication

|

Infectious Disease

|

Population Pharmacokinetics of Hydroxychloroquine Sulfate in Healthcare Workers, Given for Prophylaxis Against Coronavirus Disease 2019 (COVID‐19) in India

Jeffrey Pradeep Raj, Nithya Jaideep Gogtay, Avaneesh Pandey, Ashish Kumar Kakkar, Nusrat Shafiq, Padmaja Mekala, Usharani Pingali, Arun Prasath Raju, Surulivelrajan Mallayasamy, Nilima Arun Kshirsagar

/images/pumasai/solution-icons/pumas.png

Poster

|

|

SAEM, NLME

“SAEM in Pumas – A systematic evaluation and benchmarking”

Chris Elrod, Andreas Noack, Patrick Kofod Mogensen, Vaibhav Dixit, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png

Poster

|

|

NLME

“Analysis of Laplace Approximation for Pharmaceutical Nonlinear Mixed Effects Models”

Mohamed Tarek, Christopher Rackauckas, Patrick K. Mognesen, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/deeppumas.png

Poster

|

|

DeepNLME, Bayesian

“Bayesian Neural Ordinary Differential Equations”

Raj Dandekar, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia Valadez, Chris Rackauckas

/images/pumasai/solution-icons/pumas.png

Publication

|

|

Automatic Differentiation

“Generalizing Automatic Differentiation to Automatic Sparsity, Uncertainty, Stability, and Parallelism,”

Rackauckas, C.

/images/pumasai/solution-icons/pumas.png

Publication

|

|

Differential Equations

ModelingToolkit: A Composable Graph Transformation System For Equation-Based Modeling.

Ma, Yingbo, Shashi Gowda, Ranjan Anantharaman, Chris Laughman, Viral Shah, Chris Rackauckas

/images/pumasai/solution-icons/pumas.png

Poster

|

|

NLME

“Non-Gaussian random effects in nonlinear mixed effects models in Pumas”

Mohamed Tarek, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Optimal Design

“Nonlinear mixed effects model based optimal design of experiments using mathematical programming in Pumas”

Mohamed Tarek, Joakim Nyberg, Vijay Ivaturi, Andreas Noack

/images/pumasai/solution-icons/pumas.png

Publication

|

|

DeepNLME

Opening the Blackbox: Accelerating Neural Differential Equations by Regularizing Internal Solver Heuristics.

Pal, Avik, Yingbo Ma, Viral Shah, Christopher Rackauckas

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

“Parallel hierarchical Gibbs-NUTS MCMC algorithm for Nonlinear Mixed Effects models in Pumas”

Mohamed Tarek, Manu Francis, Vijay Ivaturi

/images/pumasai/solution-icons/pumas.png

Publication

|

Epilepsy

|

“A Prospective, Real-World, Clinical Pharmacokinetic Study to Inform Lacosamide Dosing in Critically Ill Patients Undergoing Continuous Venovenous Haemofiltration (PADRE-02).”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

/images/pumasai/solution-icons/pumas.png

Poster

|

|

Bayesian

“Subspace MCMC algorithm for Bayesian parameter estimation of hierarchical PK/PD models in Pumas”

Manu Francis, Vijay Ivaturi, Mohamed Tarek

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/lyv.png

Publication

|

Precision Dosing

|

Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software

Praneeth Jarugula, Sarah Scott, Vijay Ivaturi, Andreas Noack, Brady S. Moffet, Adnan Bhutta, Jogarao V.S. Gobburu

/images/pumasai/solution-icons/pumas.png

Publication

|

Cardio Vascular

|

Population pharmacokinetic-pharmacodynamic modeling of acetaminophen in preterm neonates with hemodynamically significant patent ductus arteriosus

Kannan Sridharan, Eman Al Ansari, Mwila Mulubwa, Arun Prasath Raju, Abdulraoof Al Madhoob, Muna Al Jufairi, Zakariya Hubail, Reem Al Marzooq, Sadeq Jaafar Radhi Hasan, Surulivelrajan Mallaysamy

/images/pumasai/solution-icons/pumas.png

Publication

|

|

“A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass.”

Strauss, Erik R., Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S. Gammie, et al.

/images/pumasai/solution-icons/pumas.png

Publication

|

Epilepsy

|

“A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01).”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan

/images/pumasai/solution-icons/pumas.png

Publication

|

|

NLME, NCA,BE, PBPK

“Accelerated Predictive Healthcare Analytics with Pumas, a High Performance Pharmaceutical Modeling and Simulation Platform.”

Rackauckas, Chris, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Simon Byrne, Shubham Maddhashiya, et al.

/images/pumasai/solution-icons/pumas.png

Publication

|

|

“Application of a Plasmin Generation Assay to Define Pharmacodynamic Effects of Tranexamic Acid in Women Undergoing Cesarean Delivery.”

Miszta, Adam, Homa K. Ahmadzia, Naomi L. C. Luban, Shuhui Li, Dong Guo, Lori A. Holle, Jeffrey S. Berger, et al.

/images/pumasai/solution-icons/pumas.png/images/pumasai/solution-icons/deeppumas.png

Publication

|

|

Bayesian, DeepNLME, NLME

“Bayesian Neural Ordinary Differential Equations,”

Dandekar, Raj, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia-Valadez, Chris Rackauckas

/images/pumasai/solution-icons/consulting.png

Publication

|

BMT

|

Characterization of Drug-Drug Interactions on the Pharmacokinetic Disposition of Busulfan in the Pediatric Hematopoietic Stem Cell Transplantation Patient

Dunn A, Ivaturi V, Paek H, Gillespie A, Brady Moffett, Gobburu J, Krance R

/images/pumasai/solution-icons/pumas.png

Publication

|

|

Population Pharmacokinetic Modeling of Belinostat and its Major Metabolite in Advanced Cancer Patients with varying degrees of Liver Dysfunction

Sumar A, Takebe N, Chen A, Kummar S, Piekarz R, Kiesel B, Moore N, Doroshow J, Beumer J, Gobburu J

/images/pumasai/solution-icons/consulting.png

Publication

|

BMT

|

“Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation”

Hechuan Wang, Aksana K. Jones, Christopher C. Dvorak, Liusheng Huang, Paul Orchard, Vijay Ivaturi, Janel Long-Boyle

/images/pumasai/solution-icons/consulting.png

Publication

|

BMT

|

“Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients”

Vijay Ivaturi, Christopher C. Dvorak, Danna Chan, Tao Liu, Morton J. Cowan, Justin Wahlstrom, Melisa Stricherz, Cathryn Jennissen, Paul J. Orchard, Jakub Tolar, Sung-Yun Pai, Liusheng Huang, Francesca Aweeka, Janel Long-Boyle

/images/pumasai/solution-icons/consulting.png

Publication

|

Precision Dosing

|

The time is now: model-based dosing to optimize drug therapy

Danna Chan, Vijay Ivaturi, Janel Long-Boyle

PumasAI.svg
Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
twittertwitter
Pumas-AI Inc.
3500 South Dupont Highway
Suite GT-101
Dover, DE 19901
Email: info@pumas.ai
twittertwitter

© Pumas-AI Inc. 2024. All rights reserved.