Bhavatharini P A, Mahendra Joshi, Archana Kakkar, Ivaturi V, et al.. “Bioequivalence Study Followed by Model Informed Dose Optimization of a Powder for Oral Suspension of 6-Mercaptopurine.”

Mohamed Tarek (1,2), Jose Storopoli (1,3), Casey Davis (4), Chris Elrod (1,5), Vijay Ivaturi (1,6). A Complete Bayesian Workflow in Pumas

Pawan Kumar Gupta, Bev Incledon, Jogarao V. S. Gobburu, Roberto Gomeni. A convolution-based in vitro-in vivo correlation model for methylphenidate hydrochloride delayed-release and extended-release capsule

Erik R. Strauss, Shuhui Li, Reney Henderson, Ross Carpenter, Dong Guo, Kiruphagaran Thangaraju, Upendra Katneni, Paul W. Buehler, Jogarao V.S. Gobburu, Kenichi A. Tanaka. “A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass”

Mohamed Tarek, Jose Storopoli, Casey Davis, Chris Elrod, Julius Krumbiegel, Chris Rackauckas, Vijay Ivaturi. A Practitioner's Guide to Bayesian Inference in Pharmacometrics using Pumas

Bunn HT, Gobburu JVS, Floryance LM. “Bayesian model-guided antimicrobial therapy in pediatrics. Front Pharmacol.”

Selig DJ, Kress AT, Nadeau RJ, DeLuca JP. Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study. Antibiotics.

Zhengqi Tan (1), Ayyappa Chaturvedula (1), Julie Desrochers (2), Kirsten Riber Bergmann (2), Yassine Kamal Lyauk (2), Rune Viig Overgaard (2). “Comparison of Pumas and NONMEM in parameter estimation of a complex pharmacodynamic model”

Niklas Korsbo, Mohamed Tarek, Chris Elrod, Antoine Soubret, Francesco Brizzi, Christopher Rackauckas, Jogarao Gobburu, Vijay Ivaturi. “DeepPumas for automatic discovery of individualizable functions governing longitudinal patient outcomes”

Gledys Reynaldo Fernandez, Leyanis Rodriguez-Vera, Jorge Duconge, Daniel Amaro, Joaquin Solozábal, Victor Mangas-Sanjuan, Iñaki Troconiz, Valvanera Vozmediano. Enlightenment on the strategic selection of pegylated rHuEPO candidates using a mechanistic model-driven extrapolation approach of the pharmacokinetics and pharmacodynamics.

Beumer JH, Kennard BC, Holleran JL, Moore N, Zlott J, Miller BM, Kummar S, Chen A, Doroshow J, Park W, Gobburu J, Dunn A. “Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions. Cancer Chemother Pharmacol.”

Mohamed Tarek [1, 2], Many Francis [3], Anastasios Panagiotelis [2]. “Fast cross-validation for Bayesian inference using proposals on a linear subspace”

Leyanis Rodriguez, Monica Rodriguez, John C Lukas, Cameron Durrant, Dale Chappell, Valvanera Vozmediano. “First-in-Pediatric Dose Selection of Lenzilumab in Rare Juvenile Myelomonocytic Leukemia”

Amira Soliman, Leyanis Rodriguez, Ana Alarcia Lacalle, Parsshava Mehta, Valvanera Vozmediano. Leveraging PBPK/PD modeling to inform drug-drug interactions and specific recommendations for pediatric labeling: Omeprazole case example

Parsshava Mehta, Serge Guzy, Valvanera Vozmediano. “Link of T-Cell Modulation and Disability Progression with High Dose Corticosteroids in Relapsing-Remitting Multiple Sclerosis using an integrative PK-semi-mechanistic PD/MBMA approach”

Mohamed Tarek, Jose Storopoli, Chris Elrod, Joga Gobbur, Vijay Ivaturi. Marginal Markov Chain Monte Carlo (MCMC)

Mohamed Tarek [1, 2], ose Storopoli [1, 3], Chris Elrod [1, 4], Joga Gobburu [1, 5], Vijay Ivaturi [1, 5]. “Marginal No-U-Turn Sampler for Bayesian Analysis in Pharmacometrics”

Salem, AM, Dvergsten, E, Karovic, S, Maitland, ML, Gopalakrishnan, M. “Model-based approach to identify predictors of paclitaxel-induced myelosuppression in “real-world” administration. CPT Pharmacometrics Syst Pharmacol.”

Pawan Kumar Gupta, Bev Incledon, Jogarao V. S. Gobburu, Roberto Gomeni. “Novel concolution-base in vitro-In vivo correlation (IVIVC) model with time scaling and bioavailability sub-models for, JORNAY PM, a methylphenidate hydrochloride delayed-release and extended-release capsule. “

Andreas Noack, Patrick Kofod Mogensen, Vijay Ivaturi. “On the error of the Laplace approximation when lags and duration parameters have between-subject variation”

Jarugula P, Akcan-Arikan A, Munoz-Rivas F, Moffett BS, Ivaturi V, Rios D. “Optimizing Vancomycin Dosing and Monitoring in Neonates and Infants Using Population Pharmacokinetic Modeling.”

Matcha, S., Raj, E.A., Mahadevan, R., et al.. “Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia.”

Saikumar Matcha, Jayashree Dillibatcha, Arun Prasath Raju, Bhim Bahadur Chaudhari, Sudheer Moorkoth, Leslie E. Lewis, Surulivelrajan Mallayasamy. “Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates”

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn. “Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia. “

Salem AM, Moffett BS, Gopalakrishnan M. “A Full Bayesian Approach for Population Pharmacokinetic/Pharmacodynamic Modeling of Unfractionated Heparin in Pediatrics.”

Chris Rackauckas, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Chris Elrod, Mohammad Tarek, Simon Byrne, Shubham Maddhashiya, José Bayoán Santiago Calderón, Michael Hatherly, Joakim Nyberg, Jogarao V.S. Gobburu, Vijay Ivaturi. “Accelerated Predictive Healthcare Analytics with Pumas, A High Performance Pharmaceutical Modeling and Simulation Platform”

Parsshava Mehta, Leyanis Rodriguez, Vijay Siripuram, Paula Muniz, Monica Rodriguez, Emili-González-Pérez3, Marta ForcadelI, Valvanera Vomediano. “Application of interspecies PBPK modeling to characterize BBB permeability using levetiracetam and acetaminophen as model drug”

Goyal RK, McManus JL, Gopalakrishnan M. “Application of Machine Learning Analysis to Inform Medical Countermeasure Development – A Case Study Using Random Forest Ensemble to Identify Predictive Biomarkers of Mortality for Hematopoietic Acute Radiation Syndrome and Confirmation of Benefit with Leukine® Across Myeloid Lineages”

Greene S, Attarwala H, Ivaturi V, Guglieri-Lopez B, Kramarczyk JF, Panther L, Natenshon, A. “Immunostimulatory/Immunodynamic Model of an mRNA-Based Vaccine Against Cytomegalovirus Infection to Guide Vaccine Dose Selection”

Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK. “Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children”

Jung D, Roem J, Ng DK, Procaccini D, Bembea MM, Gobburu JVS. “Pharmacokinetics of Plasma-derived Antithrombin III in Critically Ill Pediatric Patients Supported on Extracorporeal Membrane Oxygenation”

Li S, Feng K, Lee J, Gong Y, Wu F, Newman B, Yoon M, Fang L, Zhao L, Gobburu JVS. “Unsupervised Hierarchical Clustering Analysis for the Characterization of Sequence of Pancytopenia in Male and Female Non-human Primates Post Total Body Irradiation”

Li, S., Dvorak, C.C., Lu, Y., Chan, D., Gobburu, J.V.S., Long-Boyle, J. and Apsel Winger, B.. “Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation.”

Goyal RK, Moffett BS, Gobburu JVS, Al Mohajer M. “Population Pharmacokinetics of Vancomycin in Pregnant Women.”

Roesch E, Jain A, Micluta-Campeanu S, Rackauckas C. Pumas-QSP: A high-performance and easy-to-use modeling tool for Advanced Pharmaceutical Sciences

Dunn A, Beumer JH, Gobburu JVS. “The Effect of Liver Dysfunction on the Pharmacokinetic Disposition of Belinostat and its Metabolites in Patients with Advanced Cancers”

Husain Attarwala, Matthew Lumley, Min Liang, Vijay Ivaturi, Joe Senn. “Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia”

Goyal RK, McManus JL, Gopalakrishnan M. “Unsupervised Hierarchical Clustering Analysis for the Characterization of Sequence of Pancytopenia in Male and Female Non-human Primates Post Total Body Irradiation”

Chris Elrod, Andreas Noack, Patrick Kofod Mogensen, Vaibhav Dixit, Vijay Ivaturi. “SAEM in Pumas – A systematic evaluation and benchmarking”

Mohamed Tarek, Christopher Rackauckas, Patrick K. Mognesen, Vijay Ivaturi, Andreas Noack. “Analysis of Laplace Approximation for Pharmaceutical Nonlinear Mixed Effects Models”

Raj Dandekar, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia Valadez, Chris Rackauckas. “Bayesian Neural Ordinary Differential Equations”

Allison Dunn, Brady S. Moffett, Vijay Ivaturi, Jogarao V. S. Gobburu. “Characterization of drug–drug interactions on the pharmacokinetic disposition of busulfan in paediatric patients during haematopoietic stem cell transplantation conditioning”

Rackauckas, Christopher Vincent, Vaibhav Dixit, Adam R. Gerlach, Vijay Ivaturi. “Efficient Precision Dosing Under Estimated Uncertainties via Koopman Expectations of Bayesian Posteriors with Pumas.”

Andreas Noack, Patrick Kofod Mogensen, Joakim Nyberg, Vijay Ivaturi. “Generalized FOCE with Pumas”

Rackauckas, C.. “Generalizing Automatic Differentiation to Automatic Sparsity, Uncertainty, Stability, and Parallelism,”

Ma, Yingbo, Shashi Gowda, Ranjan Anantharaman, Chris Laughman, Viral Shah, Chris Rackauckas. ModelingToolkit: A Composable Graph Transformation System For Equation-Based Modeling.

Mohamed Tarek, Vijay Ivaturi, Andreas Noack. “Non-Gaussian random effects in nonlinear mixed effects models in Pumas”

Mohamed Tarek, Joakim Nyberg, Vijay Ivaturi, Andreas Noack. “Nonlinear mixed effects model based optimal design of experiments using mathematical programming in Pumas”

Pal, Avik, Yingbo Ma, Viral Shah, Christopher Rackauckas. Opening the Blackbox: Accelerating Neural Differential Equations by Regularizing Internal Solver Heuristics.

Mohamed Tarek, Manu Francis, Vijay Ivaturi. “Parallel hierarchical Gibbs-NUTS MCMC algorithm for Nonlinear Mixed Effects models in Pumas”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan. “A Prospective, Real-World, Clinical Pharmacokinetic Study to Inform Lacosamide Dosing in Critically Ill Patients Undergoing Continuous Venovenous Haemofiltration (PADRE-02).”

Manu Francis, Vijay Ivaturi, Mohamed Tarek. “Subspace MCMC algorithm for Bayesian parameter estimation of hierarchical PK/PD models in Pumas”

Praneeth Jarugula, Sarah Scott, Vijay Ivaturi, Andreas Noack, Brady S. Moffet, Adnan Bhutta, Jogarao V.S. Gobburu. Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software

Rackauckas, Christopher Vincent, Vaibhav Dixit, Adam R. Gerlach, Vijay Ivaturi. “Efficient Precision Dosing Under Estimated Uncertainties via Koopman Expectations of Bayesian Posteriors with Pumas.”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan. “A Prospective, Real-World, Clinical Pharmacokinetic Study to Inform Lacosamide Dosing in Critically Ill Patients Undergoing Continuous Venovenous Haemofiltration (PADRE-02).”

Rackauckas C. “Generalizing Automatic Differentiation to Automatic Sparsity, Uncertainty, Stability, and Parallelism”

Ma Yingbo, Shashi Gowda, Ranjan Anantharaman, Chris Laughman, Viral Shah, Chris Rackauckas. “ModelingToolkit: A Composable Graph Transformation System For Equation-Based Modeling.”

Pal, Avik, Yingbo Ma, Viral Shah, Christopher Rackauckas. “Opening the Blackbox: Accelerating Neural Differential Equations by Regularizing Internal Solver Heuristics.”

Davis C, Sandeep Dutta, Khamir Mehta. “A Bayesian Approach to PK/PD Modeling – A Comparison of Stan and Pumas in Julia.”

Strauss, Erik R., Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S. Gammie, et al.. “A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass.”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan. “A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01).”

Rackauckas, Chris, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Simon Byrne, Shubham Maddhashiya, et al.. “Accelerated Predictive Healthcare Analytics with Pumas, a High Performance Pharmaceutical Modeling and Simulation Platform.”

Miszta, Adam, Homa K. Ahmadzia, Naomi L. C. Luban, Shuhui Li, Dong Guo, Lori A. Holle, Jeffrey S. Berger, et al.. “Application of a Plasmin Generation Assay to Define Pharmacodynamic Effects of Tranexamic Acid in Women Undergoing Cesarean Delivery.”

Dandekar, Raj, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia-Valadez, Chris Rackauckas. “Bayesian Neural Ordinary Differential Equations,”

Dunn A, Ivaturi V, Paek H, Gillespie A, Brady Moffett, Gobburu J, Krance R. Characterization of Drug-Drug Interactions on the Pharmacokinetic Disposition of Busulfan in the Pediatric Hematopoietic Stem Cell Transplantation Patient

Wansu Park, Gobburu J, Lo L, Chonchol M, Devalaraja M. Pharmacokinetic analysis of Ziltivekimab, anti-Interleukin-6 monoclonal antibody in chronic kidney disease patients.

Sumar A, Takebe N, Chen A, Kummar S, Piekarz R, Kiesel B, Moore N, Doroshow J, Beumer J, Gobburu J. Population Pharmacokinetic Modeling of Belinostat and its Major Metabolite in Advanced Cancer Patients with varying degrees of Liver Dysfunction

Jayesh Patel, Dvorak C, Melton A, Highan C, Lu Y, Winger B, Gobburu J, Long-Boyle J. Population Pharmacokinetics of Thiotepa and its Active Metabolite, Tepa in Pediatric Patients Undergoing Hematopoietic Cell Transplantation (HCT)

Strauss, Erik R, Elyes Dahmane, Miranda Judd, Dong Guo, Brittney Williams, Michael Meyer, James S. Gammie. “A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass.”

Miszta, Adam, Homa K. Ahmadzia, Naomi L. C. Luban, Shuhui Li, Dong Guo, Lori A. Holle, Jeffrey S. Berger. “Application of a Plasmin Generation Assay to Define Pharmacodynamic Effects of Tranexamic Acid in Women Undergoing Cesarean Delivery.”

Kalaria, Shamir N., Michael Armahizer, Paul McCarthy, Neeraj Badjatia, Jogarao V. Gobburu, Mathangi Gopalakrishnan. “A Practice-Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE-01).”

Rackauckas, Chris, Yingbo Ma, Andreas Noack, Vaibhav Dixit, Patrick Kofod Mogensen, Simon Byrne, Shubham Maddhashiya. “Accelerated Predictive Healthcare Analytics with Pumas, a High Performance Pharmaceutical Modeling and Simulation Platform.”

Dandekar, Raj, Vaibhav Dixit, Mohamed Tarek, Aslan Garcia-Valadez, Chris Rackauckas. “Bayesian Neural Ordinary Differential Equations.”

Rackauckas C, Ivaturi V. Bayesian-Koopman Techniques for Optimization of Intervention with Respect to Uncertainty in PuMaS.jl.

Santiago Calderón JB, Gopalakrishnan M, Ivaturi V. Bioequivalence.jl: A suite of routines for bioequivalence (BE) analysis for the Julia language as part of the PuMaS ecosystem.

Byrne S, Noack A, Nyberg J, Rackauckas C, Ivaturi V. Comparison of Bayesian Functionality between PuMaS and NONMEM.

Ma Y, Guglieri-Lopez B, Gobburu J, Denney W, Ivaturi V. Comparison of non-compartmental analysis results between PKNCA, PuMaS.NCA and Phoenix WinNonlin.

Noack A, Ivaturi V, Nyberg J. Fast evaluation of experimental designs in non-linear mixed effects models with the PuMaS package.

Widmann D, Ivaturi V, Rackauckas C. Handling Steady-state Dosing in Stiff State-Dependent Delay Differential Equations in PuMaS.jl.

Rackauckas C, Ivaturi V. Neural-embedded nonlinear mixed effects models (NENLME) in PuMaS.jl.

Park W, Noack A, Mogenson P, Dixit V, Rackauckas C, Gobburu J, Nyberg J, Ivaturi V. Numerical and Performance comparison for Maximum Likelihood estimation methods between PuMaS.jl and industry standard software.

Jarugula P, Dixit V, Rackauckas C, Gobburu J, Ivaturi V. Physiologically-based Pharmacokinetic (PBPK) Modeling Workflow in PuMaS.

Hechuan Wang, Aksana K. Jones, Christopher C. Dvorak, Liusheng Huang, Paul Orchard, Vijay Ivaturi, Janel Long-Boyle. “Population Pharmacokinetics of Clofarabine as Part of Pretransplantation Conditioning in Pediatric Subjects before Hematopoietic Cell Transplantation”

Rackauckas, Christopher, Joakim Nyberg, Pao CSVijay Ivaturi. PKPDSimulator.Jl : A Simulation Engine for Drug Development and Clinical Therapeutics in Julia.

Perrone R, Gobburu J, Czerwiec FS, Pao CS, Ivaturi V. Estimating Short-Term Risk of Disease-Related Outcomes in ADPKD: A Prediction Model Based on Longitudinal Data From the OVERTURE Study

Vijay Ivaturi, Christopher C. Dvorak, Danna Chan, Tao Liu, Morton J. Cowan, Justin Wahlstrom, Melisa Stricherz, Cathryn Jennissen, Paul J. Orchard, Jakub Tolar, Sung-Yun Pai, Liusheng Huang, Francesca Aweeka, Janel Long-Boyle. “Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients”

Danna Chan, Vijay Ivaturi, Janel Long-Boyle. The time is now: model-based dosing to optimize drug therapy